OpenAI’s Fidji Simo Is Taking Medical Leave Amid an Executive Shake-Up

OpenAI announced a major reorganization on Friday as the company’s CEO of AGI deployment, Fidji Simo, takes medical leave to focus on her health. OpenAI president Greg Brockman will handle the product teams in Simo’s absence. Simo’s previous title was CEO of applications.

Brad Lightcap, the chief operating officer and one of CEO Sam Altman’s top deputies, is transitioning to a “special projects” role. Kate Rouch, the chief marketing officer, is taking a leave of absence to focus on her health. Rouch has been undergoing treatment for breast cancer. When she returns, it will be in “a different, more narrowly scoped role,” according to a note Simo shared with OpenAI staff which was viewed by WIRED.

“As I shared when I joined, I had a relapse of my neuroimmune condition a few weeks before starting the job,” Simo said in the note which was sent in OpenAI’s “core” Slack channel. “It’s been a bit of a rollercoaster since, and the last month has been particularly rough health-wise. For my entire time here, I’ve postponed medical tests and new therapies to stay completely focused on the job and not miss a single day of work. I took time off for the first time two weeks before the break for some medical tests, and it’s now clear that I’ve pushed a little too far and I really need to try new interventions to stabilize my health.”

Simo is expected to take “several weeks” of leave according to her internal post.

In his new role, Lightcap will be in charge of the company’s forward-deployed engineers, which embed within enterprise organizations and help integrate OpenAI’s technology, among other duties.

OpenAI will begin searching for a new CMO, Simo said. The company is also looking for a chief communications officer to replace Hannah Wong, who left her position in January. Chris Lehane has taken over as the leader of the communications team in the interim.

“We have a strong leadership team focused on our biggest priorities: advancing frontier research, growing our global user base of nearly 1 billion users, and powering enterprise use cases,” said an OpenAI spokesperson in a statement. “We’re well-positioned to keep executing with continuity and momentum.”

Simo joined OpenAI in August 2025, where she took over many of the company’s consumer-facing products, including ChatGPT, Codex, and the social-video app Sora. She recently shuttered the Sora app and told staff that the company needed to cut side projects and refocus around its core products.

The decision comes as OpenAI eyes an IPO as soon as this year. The company recently raised $122 billion in the largest funding round the tech industry has ever seen, which valued the company at $852 billion.